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KMID : 0363420050190010035
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Journal of Korean Oriental Pediatrics
2005 Volume.19 No. 1 p.35 ~ p.52
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Effect on Kami-Dangkueeumja(KDKEJ) in Atopic Dermatitis Animal Model
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Kim Yun-Hee
Han Jae-Kyung
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Abstract
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Objectives: The purpose of this study is to examine effect that KDKEJ used to atopic dermatitis disease patient get in atopy eruption control experimentally.
Methods: We analyzed the expression of IgE, IL-6, II-4, IL-5 and IL-13’s level in serum, and $IFN-{\gamma}’’$ production by KDKEJ extract. We also analyzed KDKEJ extract get to NC/Nga mine’s skin establishment analyzes neck-back skin after biopsy, and H&E method measured about epidermis and dermis part in comparison with control group.
Results: In this research KDKEJ extract as treatment result to a NC/Nga mice, IgE and IL-6 content in serum decreased remarkably than control group. And decreased than result control group which measure II-4, IL-5 and IL-13’s level in serum and $IFN-{\gamma}’’$ production secreted in Th1 cell displayed increase by KDKEJ extract. IL-4 and $IFN-{\gamma}’’$ gene revelation amount displayed marked decrease than control group in result that observe effect that get in skin of a NC/Nga mice’s skin establishment analyzes neck-back skin after biposy, and dye by H&E method decreased about epidermis and inflammation of dermis part remarkable than control group.
Conclusions: These results suggest that Th1 cell and Th2 cell observe to be shifted by secretion amount of IL-4 and $IFN-{\gamma}$ by KDKEJ extract could know that KDKEJ extract can use usefully in allergy autoimmune disease.
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KEYWORD
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NC/Nga mice, Atopic Dermatitis, Kami-Dangkueeumja
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